Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection

Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection

Author: Alexzander A.A. Asea,Ian R. Brown

Publisher: Springer Science & Business Media

ISBN: 9781402082313

Page: 373

View: 5268

With the prevalence of neurodegenerative diseases on the rise as average life expectancy increases, the hunt for effective treatments and preventive measures for these disorders is a pressing challenge. Neurodegenerative disorders such as Alzheimer’s disease, Huntington’s disease, Parkinson’s disease and amyotrophic lateral sclerosis have been termed ‘protein misfolding disorders’ that are char- terized by the neural accumulation of protein aggregates. Manipulation of the cellular stress response involving the induction of heat shock proteins offers a the- peutic strategy to counter conformational changes in neural proteins that trigger pathogenic cascades resulting in neurodegenerative diseases. Heat shock proteins are protein repair agents that provide a line of defense against misfolded, aggregati- prone proteins. Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection reviews current progress on neural heat shock proteins (HSP) in relation to neurodegenerative diseases (Part I), neuroprotection (Part II), ext- cellular HSP (Part III) and aging and control of life span (Part IV). Key basic and clinical research laboratories from major universities and hospitals around the world contribute chapters that review present research activity and importantly project the field into the future. The book is a must read for researchers, postdoctoral fellows and graduate students in the fields of Neuroscience, Neurodegenerative Diseases, Molecular Medicine, Aging, Physiology, Pharmacology and Pathology.
Categories: Medical

Heat Shock Proteins and Whole Body Adaptation to Extreme Environments

Heat Shock Proteins and Whole Body Adaptation to Extreme Environments

Author: Michael B. Evgen'ev,David G. Garbuz,Olga G. Zatsepina

Publisher: Springer

ISBN: 9401792356

Page: 218

View: 1500

For many years, the authors have investigated the adaptive role of heat shock proteins (HSPs) in different animals, including the representatives of homothermic and poikilothermic organisms that inhabit regions with contrasting thermal conditions. This book will summarize the data accumulated in the course of these studies and describe the general molecular mechanisms underlying the adaptation of various organisms to aggressive environments. We also concentrate on different evolutionary trends characteristic for HSP systems in the course of adaptation to fluctuating environmental conditions. In addition, we describe the peculiarities in the regulatory regions of heat shock genes necessary for fine tuning of these systems providing the adaptation to adverse conditions. Special emphasis is given to the role of mobile elements in the evolution and functioning of various groups of HSP genes. The book combines the results of field studies and laboratory analysis of stress genes systems.
Categories: Medical

Heat Shock Protein 60 in Human Diseases and Disorders

Heat Shock Protein 60 in Human Diseases and Disorders

Author: Alexzander A. A. Asea,Punit Kaur

Publisher: Springer Nature

ISBN: 3030231542

Page: 363

View: 4452

The book Heat Shock Protein 60 in Human Diseases and Disorders provides the most comprehensive review on contemporary knowledge on the role of HSP60 in human diseases and disorders. Using an integrative approach, the contributors provide a synopsis of novel mechanisms and signal transduction pathways. To enhance the ease of reading and comprehension the book has further been subdivided into various section including; Section I: Biomolecular Aspects of HSP60; Section II: HSP60 and Cancer; Section III: HSP60 and Inflammatory Diseases and Disorders; Section IV: HSP60 and Cardiovascular Diseases and Disorders; Section V: HSP60 and Neurological and Neurosciences; Section VI: Biomolecular Aspects of HSP60; Section VII: HSP60 and Skeletal Muscle Diseases and Disorders; and Section VIII: HSP60 in Human Health. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Neurology & Neuroscience, Oncology, Cardiovascular Disease, Skeletal Muscle Diseases and Disorders, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.
Categories: Science

Heat Shock Protein-Based Therapies

Heat Shock Protein-Based Therapies

Author: Alexzander A.A. Asea,Naif N. Almasoud,Sunil Krishnan,Punit Kaur

Publisher: Springer

ISBN: 3319172115

Page: 385

View: 9869

The book Heat Shock Protein-Based Therapies provides the most up-to-date review on new heat shock protein-based mechanisms used in the therapy and treatment of various human disorders and diseases, including cancer, muscular atrophy, neurodegenerative disorders (Alzheimer's Disease, Multiple Sclerosis) and infectious diseases (HIV, periodontal disease). Written by leaders in the field of heat shock protein research, the chapters systematically and in a step wise fashion takes the reader through the fascinating sequence of events by which mechanisms dependent on heat shock proteins are targeted. The chapters also provide answers as to HSP biological significance to the host. This book is a must read for graduate and postgraduates in the field of Drug Development, Biotechnology, Pharmaceutical Industry, Phytomedicine, Biology (plant and mammal), Biochemistry (pro- and eukaryotic), Oncology, Immunology, Microbiology, Exercise Medicine, Physiology, Inflammatory diseases, Autoimmunity, Pharmacology and Pathology.
Categories: Medical

HSP70 in Human Diseases and Disorders

HSP70 in Human Diseases and Disorders

Author: Alexzander A. A. Asea,Punit Kaur

Publisher: Springer

ISBN: 3319895516

Page: 403

View: 7249

The book HSP70 in Human Diseases and Disorders provides the most comprehensive review on contemporary knowledge on the role of HSP70 family - one of the most studied HSP - in human diseases and disorders. Using an integrative approach to expand our current understanding of HSP70 functions, the contributors provide a synopsis of novel mechanisms by which HSP70 is involved in the regulation of human diseases and disorders. Key basic and clinical research laboratories from major universities and academic medical hospitals around the world contribute chapters that review present research activity and importantly project the field into the future. The book is a must read for medical students and residents, clinical and basic science researchers, postdoctoral fellows and graduate students in the fields of Medicine, Physiology, Clinical Trials, Biotechnology, Molecular Medicine and Pathology.
Categories: Medical

Aging, Cancer and Age-related Disease

Common Mechanisms

Aging, Cancer and Age-related Disease

Author: Robert M. Tanguay

Publisher: Wiley-Blackwell

ISBN: N.A

Page: 300

View: 3862

"This volume presents manuscripts stemming from the 13th Congress of the International Association of Biomedical Gerontology entitled 'Aging, Cancer, and Age-Related Diseases: common Mechanisms?' held on May 18-20, 2009 in Quebec City, Quebec, Canada"--P. [iii].
Categories: Medical

Heat Shock Proteins in Neural Cells

Heat Shock Proteins in Neural Cells

Author: Christiane Richter-Landsberg

Publisher: Springer Science & Business Media

ISBN: 9780387399546

Page: 115

View: 3510

This valuable new title addresses the role of heat shock proteins and cellular stress responses in the brain, with a major focus on nerve cells and glia, namely oligodendrocytes and astrocytes. Heat shock proteins are involved in many physiological processes, including development and differentiation, organisation of the cytoarchitecture by binding to cytoskeletal elements, and regulation of the balance between cell death and survival.
Categories: Medical

Parkinson's Disease

Diagnosis & Clinical Management : Second Edition

Parkinson's Disease

Author: Dr. Stewart A. Factor, DO,Dr. William Weiner, MD

Publisher: Demos Medical Publishing

ISBN: 9781934559871

Page: 1024

View: 3259

Parkinson's disease (PD) is the second most common neurodegenerative disease in the world. Still the only major text on the subject, the completely revised and updated second edition of Parkinson's Disease: Diagnosis and Clinical Management comes at a time when specialists have made important advances in our understanding of the etiology, pathogenesis, investigation, and management of Parkinson's disease. The book includes 23 completely new chapters, and has updated information on: Genetics Pathology Biomarkers Pathogenesis Impulse control disorders in Parkinson's disease Updated outcome measures Complementary and alternative medicine for the treatment of Parkinson's disease Together the chapters form a comprehensive review of the many issues facing PD physicians today. Lucid and easily readable from beginning to end, each chapter may also stand on its own as a scholarly review of the individual subject. Each one is concisely written and heavily referenced for this purpose. The second edition of Parkinson's Disease: Diagnosis and Clinical Management provides a state-of-the-art review of where we've been, where we are now, and where we are going in treating this disease.
Categories: Medical

Brain Injury Medicine

Principles and Practice

Brain Injury Medicine

Author: Douglas I Katz, MD,Ross D Zafonte, DO,Nathan D Zasler, MD, FAAPM&R, FAADEP, DAAPM

Publisher: Demos Medical Publishing

ISBN: 9781934559505

Page: 176

View: 6276

A Doody's Core Title 2012 Brain Injury Medicine: Principles and Practice is a comprehensive guide to all aspects of the management issues involved in caring for the person with brain injury - from early diagnosis and evaluation through the post-acute period and rehabilitation. It is the definitive core text needed by all practitioners in this area, including physiatrists, neurologists, psychologists, nurses, and other health care professionals. Written by over 100 acknowledged leaders in the field, and containing hundreds of tables, graphs, and photographic images, the text deals with issues of neuroimaging and neurodiagnostic testing, prognosis and outcome, acute care, rehabilitative care, treatment of specific populations, neurologic problems following injury, neuromusculoskeletal problems, and general management issues. Key features include: Emphasis on a disease state management approach to patient assessment and treatment Promotion of a holistic, biopsychosocial model of patient assessment and care Review of current expert consensus on practice guidelines Exploration of epidemiologic and basic pathophysiologic aspects of brain injury Examination of clinical issues throughout the continuum of rehabilitative care Cutting edge, practical information based on the authors' extensive clinical experience that will positively impact patients and families following brain injury
Categories: Medical

Stroke E-Book

Pathophysiology, Diagnosis, and Management

Stroke E-Book

Author: J. P. Mohr,Philip A. Wolf,Michael A. Moskowitz,Marc R Mayberg,Rudiger Von Kummer

Publisher: Elsevier Health Sciences

ISBN: 1437737803

Page: 1520

View: 9284

First published in 1986 under the editorial direction of Dr. Henry J.M. Barnett, Stroke: Pathophysiology, Diagnosis, and Management continues to provide the dependable, current answers you need to effectively combat the increasing incidence of this disease. Dr. J.P. Mohr, together with new associate editors Philip A. Wolf, James C. Grotta, Michael A. Moskowitz, Marc Mayberg, and Rüdiger von Kummer as well as a multitude of expert contributors from around the world, offer you updated and expanded coverage of mechanisms of action of commonly used drugs, neuronal angiogenesis and stem cells, basic mechanisms of spasm and hemorrhage, prevention of stroke, genetics/predisposing risk factors, and much more, equipping you to understand the latest scientific discoveries and make effective use of the newest approaches to diagnosis and treatment. Gain fresh perspectives and up-to-date insights from the world’s leading authorities on the pathophysiology, diagnosis, and management of stroke. Access the comprehensive, expert clinical guidance you need to recognize the clinical manifestations of stroke, use the latest laboratory and imaging studies to arrive at a diagnosis, and generate an effective medical and surgical treatment plan. Make efficient and accurate diagnoses with the aid of abundant full-color CT images and pathology slides. Stay up to date on hot topics such as mechanisms of action of commonly used drugs, neuronal angiogenesis and stem cells, basic mechanisms of spasm and hemorrhage, prevention of stroke, genetics/predisposing risk factors, and much more.
Categories: Medical