Haemoglobinopathy Diagnosis

Haemoglobinopathy Diagnosis

This important text: Contains a practical, highly illustrated, approach to the laboratory diagnosis of haemoglobin disorders Includes "test-yourself" questions and provides an indispensable tool for learning and teaching Presents new ...

Author: Barbara J. Bain

Publisher: John Wiley & Sons

ISBN: 9781119579991

Category: Medical

Page: 448

View: 791

An updated, essential guide for the laboratory diagnosis of haemoglobin disorders This revised and updated third edition of Haemoglobinopathy Diagnosis offers a comprehensive review of the practical information needed for an understanding of the laboratory diagnosis of haemoglobin disorders. Written in a concise and approachable format, the book includes an overview of clinical and laboratory features of these disorders. The author focuses on the selection, performance, and interpretation of the tests that are offered by the majority of diagnostic laboratories. The book also explains when more specialist tests are required and explores what specialist referral centres will accomplish. The information on diagnosis is set in a clinical context. The third edition is written by a leading haematologist with a reputation for educational excellence. Designed as a practical resource, the book is filled with illustrative examples and helpful questions that can aide in the retention of the material presented. Additionally, the author includes information on the most recent advances in the field. This important text: • Contains a practical, highly illustrated, approach to the laboratory diagnosis of haemoglobin disorders • Includes “test-yourself” questions and provides an indispensable tool for learning and teaching • Presents new material on antenatal screening/prenatal diagnostic services • Offers myriad self-assessment case studies that are ideal for the trainee Written for trainees and residents in haematology, practicing haematologists, and laboratory scientists, Haemoglobinopathy Diagnosis is an essential reference and learning tool that provides a clear basis for understanding the diagnosis of haemoglobin disorders.
Categories: Medical

Practical Management of Haemoglobinopathies

Practical Management of Haemoglobinopathies

BM] 1999; 318: 1585-90. 16. Bain J. Haemoglobinopathy Diagnosis. Blackwell
Science, 2001. 17. British Committee for Standards in Haematology. Oxford:
Guidelines on the laboratory diagnosis of haemoglo— binopathies. Br]
Haematol1998 ...

Author: Iheanyi Okpala

Publisher: John Wiley & Sons

ISBN: 9781405140201

Category: Medical

Page: 256

View: 154

Presents a comprehensive picture of care, including diagnostic, therapeutic, and psychosocial aspects. The contributors cover basic science and epidemiological aspects of the public health challenge, but maintain a focus on the day to day issues encountered in dealing with affected people. Containing clear, practical advice, this text is an essential, practical resource to bridge the gap between expensive reference texts and smaller manuals. Practical Management of Haemoglobinopathies is an ideal for; Trainees and residents in haematology Hematologists in practice Healthcare professionals treating those with sickle cell disease and thalassaemia Why Buy This Book? Deals with practical problems encountered in the comprehensive care of affected individuals Each chapter written by an expert in the field Comprehensive coverage of basic science, laboratory diagnosis, psychosocial support and community care
Categories: Medical

Variant Haemoglobins

Variant Haemoglobins

This book covers 150 normal and variant haemoglobins that have been studied and carefully documented. Variant Haemoglobins has four introductory chapters followed by an invaluable atlas.

Author: Barbara J. Bain

Publisher: John Wiley & Sons

ISBN: 9781444347678

Category: Medical

Page: 260

View: 193

Variant Haemoglobins – A Guide to Identification is based on the premise that any single diagnostic technique offers only a very provisional identification of a variant haemoglobin. In routine diagnostic practice two techniques are needed as a minimum, with the results being interpreted in the light of the clinical details, blood count, blood film and ethnic origin. This book covers 150 normal and variant haemoglobins that have been studied and carefully documented. Variant Haemoglobins has four introductory chapters followed by an invaluable atlas. The introductory chapters cover the genetics of haemoglobin synthesis the principles of tests employed for identification common haemoglobins of major clinical or diagnostic importance thalassaemias and related conditions The atlas section comprises 170 full colour pages in which each variant haemoglobin or combination of haemoglobins is illustrated by cellulose acetate electrophoresis at alkaline pH, agarose gel electrophoresis at acid pH, isoelectric focusing and one or more HPLC traces. For ease of reference, the atlas pages are arranged according to the retention time of each haemoglobin on HPLC, this becoming increasingly the primary technique employed in haemoglobin identification. Bringing a mix of necessary scientific expertise and clinical knowledge, each author has more than 30 years experience in the diagnosis of variant haemoglobins. Providing otherwise unavailable information, this unique and practical guide is illustrated with over 700 high quality colour digital images plus flow charts and line diagrams covers common and important haemoglobin variants, in addition to many rarer ones is an essential reference source for diagnosis in the haematology laboratory A remarkably useful book, Variant Haemoglobins will be valuable for haematopathologists, clinical and laboratory haematologists in practice and in training and all laboratory staff involved in haemoglobinopathy diagnosis.
Categories: Medical

Tietz Textbook of Clinical Chemistry and Molecular Diagnostics E Book

Tietz Textbook of Clinical Chemistry and Molecular Diagnostics   E Book

Haemoglobinopathy diagnosis. London: Blackwell, 2001.) Hemoglobinopathies,
the most common single gene disorder in the world, are structural Hb variants
arising from mutations in the globin genes, which result in substitutions or ...

Author: Carl A. Burtis

Publisher: Elsevier Health Sciences

ISBN: 9781455759422

Category: Medical

Page: 2256

View: 408

As the definitive reference for clinical chemistry, Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 5th Edition offers the most current and authoritative guidance on selecting, performing, and evaluating results of new and established laboratory tests. Up-to-date encyclopedic coverage details everything you need to know, including: analytical criteria for the medical usefulness of laboratory procedures; new approaches for establishing reference ranges; variables that affect tests and results; the impact of modern analytical tools on lab management and costs; and applications of statistical methods. In addition to updated content throughout, this two-color edition also features a new chapter on hemostasis and the latest advances in molecular diagnostics. Section on Molecular Diagnostics and Genetics contains nine expanded chapters that focus on emerging issues and techniques, written by experts in field, including Y.M. Dennis Lo, Rossa W.K. Chiu, Carl Wittwer, Noriko Kusukawa, Cindy Vnencak-Jones, Thomas Williams, Victor Weedn, Malek Kamoun, Howard Baum, Angela Caliendo, Aaron Bossler, Gwendolyn McMillin, and Kojo S.J. Elenitoba-Johnson. Highly-respected author team includes three editors who are well known in the clinical chemistry world. Reference values in the appendix give you one location for comparing and evaluating test results. NEW! Two-color design throughout highlights important features, illustrations, and content for a quick reference. NEW! Chapter on hemostasis provides you with all the information you need to accurately conduct this type of clinical testing. NEW! Six associate editors, Ann Gronowski, W. Greg Miller, Michael Oellerich, Francois Rousseau, Mitchell Scott, and Karl Voelkerding, lend even more expertise and insight to the reference. NEW! Reorganized chapters ensure that only the most current information is included.
Categories: Medical

The Midwives Guide to Key Medical Conditions E Book

The Midwives  Guide to Key Medical Conditions E Book

... parents cope with a child with sickle cell disorder or thalassaemia. Health
Society Care in the Community 8(1):57–69 Bain B J 2001 Haemoglobinopathy
diagnosis: The a, b, g, and d thalassaemias and related conditions. Blackwell,
London ...

Author: Linda Wylie

Publisher: Elsevier Health Sciences

ISBN: 9780702039850

Category: Medical

Page: 188

View: 496

The only book of its kind, this essential reference offers quick access to information on the effects medical conditions can have on pregnancy and childbirth. Coverage includes a brief overview of normal anatomy and physiology with concise, practical guidelines for managing disorders commonly seen in women of childbearing age. From mild diseases such as asthma to serious conditions such as heart lesions, this indispensable guide will help you manage pregnancy and childbirth in women with systemic disease, recognize the early onset of disease-related pregnancy complications, and determine when it may be necessary to refer patients to a specialist. Offers complete coverage of normal pathophysiology in both the general population and in the context of pregnancy and childbirth. Provides comprehensive midwifery management guidelines. Outlines potential consequences of disease-related complications for the fetus or neonate.
Categories: Medical

Practical Paediatrics E Book

Practical Paediatrics E Book

Table 10.1.4 Prenatal diagnostic tests cVs fetal blood sampling or fetal biopsies
tissue sampled chorionic villi derived ... risk of fetal chromosome anomaly when
rapid results are required diagnosis of fetal haemoglobinopathy diagnosis of fetal
 ...

Author: Michael South

Publisher: Elsevier Health Sciences

ISBN: 9780702051265

Category: Medical

Page: 848

View: 335

This is the seventh edition of a highly regarded, major textbook of paediatrics. Key features Empahasis on differential diagnosis from a presenting-problem point of view.. Covers the social and preventative aspects of child health Covers the common diseases of childhood and their treatment with a presenting-problem approach Contextualises the disease in description of social, genetic and epidemiological factors. Clinical example boxes throughout Key learning points in Practical Points boxes throughout Clearly sign-posted text Plus Free online access to the whole book through www.studentconsult.com, where you will also find: Over 500 interactive self-assessment questions Further reading suggetions Links to other helpful online resources Additional illustrations Empahasis on differential diagnosis from a presenting-problem point of view.. Covers the social and preventative aspects of child health Covers the common diseases of childhood and their treatment with a presenting-problem approach Contextualises the disease in description of social, genetic and epidemiological factors. Clinical example boxes throughout Key learning points in Practical Points boxes throughout Clearly sign-posted text Plus Free online access to the whole book through www.studentconsult.com, where you will also find: Nearly 400 interactive self-assessment questions Further reading suggetions Links to other helpful online resources Additional illustrations 51 new chapter authors New chapter on sleep problems New chapter on refugee health All chapters updated, with several major re-writes Plus Free online access to the whole book through www.studentconsult.com, where you will also find: Nearly 400 interactive self-assessment questions Further reading suggestions Helpful references Additional illustration
Categories: Medical

Dacie and Lewis Practical Haematology E Book

Dacie and Lewis Practical Haematology E Book

Diabetes mellitus diagnosed following request for haemoglobin electrophoresis.
Lancet 2002;117:778. Borbely N, Phelan L, Szydlo R, et al. Capillary zone
electrophoresis for haemoglobinopathy diagnosis. J Clin Pathol 2013; 66:29–39.

Author: Barbara J. Bain

Publisher: Elsevier Health Sciences

ISBN: 9780702069253

Category: Medical

Page: 600

View: 737

For more than 65 years, this best-selling text by Drs. Barbara J. Bain, Imelda Bates, and Mike A. Laffan has been the worldwide standard in laboratory haematology. The 12th Edition of Dacie and Lewis Practical Haematology continues the tradition of excellence with thorough coverage of all of the techniques used in the investigation of patients with blood disorders, including the latest technologies as well as traditional manual methods of measurement. You’ll find expert discussions of the principles of each test, possible causes of error, and the interpretation and clinical significance of the findings. A unique section on haematology in under-resourced laboratories. Ideal as a laboratory reference or as a comprehensive exam study tool. Each templated, easy-to-follow chapter has been completely updated, featuring new information on haematological diagnosis, molecular testing, blood transfusion- and much more. Complete coverage of the latest advances in the field. An expanded section on coagulation now covers testing for new anticoagulants and includes clinical applications of the tests.
Categories: Medical

Haemophilia

Haemophilia

b HAEMOGLOBINOPATHY DIAGNOSIS By Barbara J. Bain Blackwell Science
Osney Mead , Oxford OX2 OEL UK ... in the diagnosis of haemoglobinopathies
are due to a failure in collecting correct laboratory data , or because of incorrect ...

Author:

Publisher:

ISBN: NWU:35558005075664

Category:

Page:

View: 553

Categories:

Clinical Genetics in Nursing Practice

Clinical Genetics in Nursing Practice

... B. J. (2001), Haemoglobinopathy diagnosis. Oxford, England: Blackwell
Science. Bakanay, S. M., Dainer, E., Clair, B., Adekile, A., Daitch, L., Wells, L., et
al. (2005). Mortality in sickle cell patients on hydroxyurea therapy. Blood, 105,545
–547.

Author: Felissa R. Lashley, PhD, RN, FABMGG

Publisher: Springer Publishing Company

ISBN: 0826123678

Category: Medical

Page: 584

View: 951

Designated a Doody's Core Title! The third edition of this award-winning text provides new and updated knowledge about genetics issues relevant to nursing practice. Read in sequence or used as a reference, this is a comprehensive overview of how genetics affetcs the care that nurses provide. In addition to a summary of basic human genetics and discussion of the Human Genome Project, this new edition includes the latest research findings and implications about inheritance, major genetic disorders (cytogenetics or chromosomal, inherited biochemical, and congenital anomalies), and genetics in twin studies. A consideration of the ethical impact of genetics on society and future generations, as well as information on assisted reproduction round out the overview. Includes over 100 illustrations and photos of specific genetic disorders; tables and figures on the distribution of disease; and an extensive appendix listing associations, organizations, and websites relevant to genetics.
Categories: Medical

Ethnic Factors in Health and Disease

Ethnic Factors in Health and Disease

Carriers can therefore be advised prospectively that, if by chance they mate with
another carrier, they have a 1 in 4 risk in each pregnancy of producing a child
with a major haemoglobinopathy. Prenatal diagnosis is now available in the ...

Author: J. K. Cruickshank

Publisher: Butterworth-Heinemann

ISBN: 9781483165417

Category: Political Science

Page: 344

View: 961

Ethnic Factors in Health and Disease discusses ethnicity from a medical perspective. The book is comprised of 35 chapters that are grouped into four sections. The text first covers the background issues concerning the relationship between ethnicity and health. The next part deals with topics related to epidemiology, such as the health of migrants and interethnic comparison of cardiovascular disease. Next, the book tackles the sociology of health; this part covers occupational status, housing, and racism. The last part discusses the specific medical aspects, including pregnancy, viral infections, and cardiovascular disease. The book will be of great use to medical researchers and practitioners. Professionals dealing with ethnicity, such as sociologists, anthropologists, and psychologists will also benefit from this book.
Categories: Political Science

Guide to Diagnostic Tests Seventh Edition

Guide to Diagnostic Tests Seventh Edition

Molecular tests are also used to confirm hemoglobinopathy (eg, β-thalassemia).
Presence of HbS with HbA > HbS: sickle cell ... Haemoglobinopathy diagnosis:
algorithms, lessons and pitfalls. Blood Rev 2011;25:205. [PMID:21596464] Piel ...

Author: Diana Nicoll

Publisher: McGraw Hill Professional

ISBN: 9781259640902

Category: Medical

Page:

View: 994

The essential guide to more than 450 of the most commonly performed diagnostic tests – updated with the latest molecular, genetic, and microbiological tests A Doody's Core Title for 2017! Guide to Diagnostic Tests, Seventh Edition is a concise guide to the selection and interpretation of more than 450 of the laboratory and microbiology tests most relevant to the general practice of medicine. This on-the-spot clinical companion also includes coverage of diagnostic imaging, electrocardiology, echocardiography, and the use of tests in differential diagnosis. Features: • Covers areas of internal medicine, pediatrics, surgery, neurology, and obstetrics and gynecology • Over 25 new or substantially revised laboratory tests • New and updated coverage of emerging and re-emerging pathogens and infectious agents,including the Zika and Ebola viruses • Updated material on molecular and genetic tests, including pharmacogenetics tests • An entire section of diagnostic algorithms • Full literature citations with PubMed identification (PMID) numbers included for each reference • Details costs and risks of various procedures and tests • Full section on electrocardiography and echocardiography If you’ve been looking for an authoritative, up-to-date, and easy-to-carry guide to the latest diagnostic testing procedures, your search ends here.
Categories: Medical

Medical Problems in Dentistry E Book

Medical Problems in Dentistry E Book

Haemoglobinopathies The fetus is normally born with fetal haemoglobin (HbF) as
the main haemoglobin and, in infancy, this is replaced ... The diagnosis of
haemoglobinopathy rests on the history, examination and laboratory
investigations.

Author: Crispian Scully

Publisher: Elsevier Health Sciences

ISBN: 9780702044090

Category: Medical

Page: 768

View: 717

This text offers an authoritative account of general medical and surgical conditions as they apply to the practice of dentistry and oral healthcare. Now established as the standard reference on the subject, Medical Problems in Dentistry is essential for students learning for the first time or practitioners needing to keep up-to-date with their knowledge. Detailed coverage outlines the complete relevance of systemic diseases and their treatment to dentistry – essential knowledge for the whole dental team User-friendly format allows ease of access to information whether for exam revision purposes or for a specific issue confronting staff in a busy clinical environment Clearly written with excellent use of illustrations, the book is an essential, easy to use, reliable source of information Text completely updated and re-organised to increase focus on the more dentally-relevant aspects of medicine and subject areas that have undergone recent change Entries more fully alphabetized to improve access to information Accompanying ‘key points boxes’ highlight the most crucial aspects of specific medical conditions Content peer-reviewed by a specialist Advisory Board to ensure accuracy of information and the inclusion of the latest advances Additional coverage of autoinflammatory disorders, biological response modifiers, craniofacial transplantation, drug reactions, drug-resistant microbial infections, osteonecrosis, and immune reconstitution syndrome Completely new entries such as alternative and complementary medicine, health promotion, men’s issues and occupational health New national and international guidelines, selected recent references and up-to-date websites
Categories: Medical

The Genetics of Cardiovascular Disease

The Genetics of Cardiovascular Disease

Alter BP: Prenatal diagnosis of hemoglobinopathies and other hematologic
diseases. J Pediatr 95:501–513, 1979. Boehm CD, Antonarakis SE, Phillips JA III,
Stetten G, Kazazian HH Jr: Prenatal diagnosis using DNA polymorphisms.
Reports ...

Author: Mary Ella Mascia Pierpont

Publisher: Springer Science & Business Media

ISBN: 9781461323051

Category: Medical

Page: 374

View: 208

Over the past 25 years, the growing impor cardiovascular. We hope that by having this tance of genetic factors in the basic understand compilation of cardiovascular diseases in one ing of human cardiovascular disease has become source, it will be of value to all who are involved apparent. Prior to this time, there was an era in the care of patients with cardiovascular dis when cardiovascular disease was first viewed at ease or their families. the diagnostic level followed by an era when The first six chapters of this book delineate cardiovascular disease was viewed at a treatment conditions related to congenital cardiac mal level. The first era occurred at the turn of the formations. Their etiology is not precisely century with the first clinical recognition of known, so we have included chapters that dis symptoms and patterns for diagnosis of car cuss many aspects of congenital cardiac mal diovascular diseases. The development of formations. The first chapter provides discus diagnostic methodology, such as radiographic sion of mechanisms of maldevelopment of the studies and electrocardiography, led to marked heart. We believe that these mechanisms pro changes in our understanding of cardiovascular vide a basis for understanding the genetic and disease. This era was followed by improved environmental factors which operate to produce methods of medical treatment, introduction congenital cardiac malformations. Chapter 2 describes the occurrence of con of medication such as antibiotics, and more genital cardiac malformations in families and sophisticated surgical techniques.
Categories: Medical

A Laboratory Guide to Clinical Diagnosis

A Laboratory Guide to Clinical Diagnosis

THALASSAEMIA MINOR PLUS HETEROZYGOUS ABNORMAL
HAEMOGLOBINOPATHY Diagnosis is confirmed by the finding of very large
numbers of target cells in the peripheral blood, with decreased red-cell saline
osmotic fragility, and ...

Author: R.D. Eastham

Publisher:

ISBN:

Category:

Page:

View: 778

Categories:

Diagnosis and Management of Dental Caries

Diagnosis and Management of Dental Caries

A complex haemoglobinopathy diagnosis in a family with both beta ( degree ) -
and alpha ( [ degree ] / + )thalassaemia homozygosity . European Journal of
Human Genetics . 1999 ; 7 : 163-168 . Glenn FB . Immunity conveyed by a
fluoride ...

Author:

Publisher: Department of Health and Human Services Agency Earch and Quality

ISBN: CHI:58506657

Category: Dental caries

Page: 269

View: 846

Categories: Dental caries

Clinical Biochemistry E Book

Clinical Biochemistry E Book

Clinical picture and/or blood count or film suggestive of a haemoglobinopathy Hb
Electrophoresis Hb variants, e.g. S,C,D,E ... unstable Hb Heinz O2 affinity bodies
FIGURE 29.4 □ A simple algorithm for the diagnosis of haemoglobinopathies.

Author: William J. Marshall

Publisher: Elsevier Health Sciences

ISBN: 9780702054785

Category: Medical

Page: 996

View: 809

Essential reading for candidates for the MRCPath examination and similar postgraduate examinations in clinical biochemistry. The book gives an overview of the acquisition of data, as well as concentrating on clinical aspects of the subject, giving detailed coverage of all conditions where clinical biochemistry is used in diagnosis and management. In common with other diagnostic specialties clinical biochemistry now uses an increasing number of techniques involving the 'new biology': these are covered in this book. It is also increasingly common for medically qualified clinical biochemists to become involved in the clinical management of patients (eg nutritional support) and material on this will be included. From the author of the popular Clinical Chemistry medical student textbook. Although there are many competing texts on clinical chemistry, the vast majority concentrate on the technology; this book concentrates on the clinical. Ideally suited for preparation for the MRCPath and similar examination. Significant changes to content to reflect changes in how clinical chemistry services are organised and to reflect the advent of metabolic medicine as a recognised specialty. Chapter on Clinical biochemistry of nutrition to include new information on regulation of appetite and the clinical management of obesity. New chapter to bring together information on inborn errors of metabolism affecting adults. New chapter on clinical biochemistry of cardiovascular disease. The diabetes chapter has been split into two separate chapters to allow more detailed description of the practical clinical management of the disease.
Categories: Medical

Diagnostic Techniques in Genetics

Diagnostic Techniques in Genetics

3 DPG concentration ) or in the haem production ( iron deficiency ) will have an
effect on the consequences of a haemoglobinopathy . Phenotypic diagnosis of
haemoglobinopathies The phenotypic diagnosis of haemoglobinopathies is a ...

Author: Jean-Louis Serre

Publisher: Wiley-Blackwell

ISBN: UOM:39015063085271

Category: Medical

Page: 256

View: 311

Diagnostic Techniques in Genetics offers an overview of how DNA or RNA technology may be applied to a large set of genetic diagnoses. The first part of the book focuses on DNA/RNA applications and includes many of the latest developments in the field combined with routine procedures of genetic diagnoses, for example cloning and sequencing DNA. The DNA applications presented in the first chapter are then each applied to a specific kind of genetic diagnosis and the text concludes with a chapter devoted to population genetics.
Categories: Medical

Diagnosis in Paediatric Haematology

Diagnosis in Paediatric Haematology

Table 2 . 8 Laboratory investigations for suspected haemoglobinopathy Only 22
Diagnosis in paediatric haematology Congenital erythropoietic protoporphyria
Congenital microcytic anaemia with iron overload Haemoglobinopathies.

Author: Harry Smith

Publisher:

ISBN: UOM:39015037325316

Category: Medical

Page: 338

View: 645

This illustrated diagnostic manual of paediatric blood disease concentrates on the laboratory manifestations of disease (ie, unusual cells in blood films), rather than on clinical features. The book offers a collection of pictures of both common and rare conditions.
Categories: Medical