Chiral Separations by Chromatography

Chiral Separations by Chromatography

" "This book will be a reliable guide for those just starting out in pharmaceutical and related industries, as well as those with experience in the field."--Jacket.

Author: Satinder Ahuja

Publisher: Amer Chemical Society

ISBN: UOM:39015042594211

Category: Science

Page: 244

View: 342

A large number of examples are given that will assist in the selection of a method, including thin-layer chromatography, capillary electrophoresis and membrane separations." "This book will be a reliable guide for those just starting out in pharmaceutical and related industries, as well as those with experience in the field."--Jacket.
Categories: Science

Chiral Separation Methods for Pharmaceutical and Biotechnological Products

Chiral Separation Methods for Pharmaceutical and Biotechnological Products

This book provides researchers and students an under-standing of chiral separations and offers a convenient route to selecting the best separation method, saving considerable time and cost in product development.

Author: Satinder Ahuja

Publisher: John Wiley & Sons

ISBN: 1118097750

Category: Science

Page: 400

View: 980

Discusses chiral separations and offers guidance for selectingthe optimum method for desired results Chiral separations represent the most intriguing and, by somemeasures, most difficultseparations of chemical compounds. Thisbook provides researchers and students an under-standing of chiralseparations and offers a convenient route to selecting the bestseparation method, saving considerable time and cost in productdevelopment. Considering chiral separations in the biotechnological andpharmaceutical industries, as well as for food applications, Dr.Ahuja provides insights into a broad range of topics. Opening witha broad overview of chiral separations, regulatory considerationsin drug product development, and basic issues in methoddevelopment, the book: Covers a variety of modern methods such as gas chromatography,high performance liquid chromatography, supercritical fluidchromatography, and capillary electrophoresis Deals with the impact of chirality on the biological activity ofsmall and large molecules Provides detailed information on useful chiral stationary phases(CSPs) for HPLC Includes handy information on selection of an appropriate CSP,including mechanistic studies Offers strategies for fast method development with HPLC, SFC,and CE Discusses preparatory methods utilized in the pharmaceuticalindustry With in-depth discussions of the current state of the field aswell as suggestions to assist future developments, ChiralSeparation Methods for Pharmaceutical and BiotechnologicalProducts is an essential text for laboratory investigators,managers, and regulators who are involved in chiral separations inthe pharmaceutical industry, as well as students preparing forcareers in these fields.
Categories: Science

Chiral Chromatography

Chiral Chromatography

Chiral Chromatography Thomas E. Beesley Advanced Separation Technologies Inc.

Author: Thomas E. Beesley

Publisher: John Wiley & Sons

ISBN: 0471974277

Category: Science

Page: 522

View: 581

Chiral Chromatography Thomas E. Beesley Advanced Separation Technologies Inc., Whippany, New Jersey, USA Raymond P. W. Scott Chemistry Department, Georgetown University, Washington DC, USA and Chemistry Department, Birkbeck College, University of London, UK Analytical techniques based on separation processes, such as chromatography and electrophoresis, are finding a growing range of applications in chemical, pharmaceutical and clinical laboratories. The Wiley Separation Science Series provides the analyst in these laboratories with well-focused books covering individual techniques, so that they can be applied more efficiently and effectively to contemporary analytical problems. The different enantiomers of a drug can exhibit widely different physiological activity in degree and nature. As a result, the separation and identification of enantiomers is now a very important analytical problem and chiral chromatography is the natural technique to apply to the resolution of such mixtures. Chiral Chromatography provides the reader with a basic understanding of the nature of chromatographic separations and relates the principles specifically to the separation of enantiomers. The following information is included: * chiral separations involving both gas and liquid chromatography * descriptions of the apparatus used for both techniques * detailed discussion on the retention mechanism that results in chiral selectivity * the structure and synthesis of a wide range of chirally active stationary phases used in both gas and liquid chromatography * preparative applications for large scale purification of enantiomers * applications of capillary electrophoresis and capillary electrochromatography. In addition to the above, a large number of examples of the separation of both commercially and physiologically interesting chiral mixtures are given, as is a detailed discussion on the mechanism of selectivity of each example. Thomas Beesley was founder and is the CEO for a leading manufacturer of chiral stationary phases and has published papers on TLC, HPLC and chiral separations involving cyclodextrins. He has also coauthored papers with Daniel W. Armstrong, an expert on modern cyclodextrin columns. Raymond Scott has worked in the field of separation science for over 40 years and has contributed extensively to the development of both gas and liquid chromatography publishing over 160 papers on the subjects.
Categories: Science

Chiral Separations

Chiral Separations

Prominent experts from around the world detail the chromatographic and electroseparation techniques they have developed for chiral separations on an analytical scale.

Author: Gerald Gübitz

Publisher: Springer Science & Business Media

ISBN: 9781592596485

Category: Science

Page: 448

View: 942

Prominent experts from around the world detail the chromatographic and electroseparation techniques they have developed for chiral separations on an analytical scale. Described in step-by-step detail to ensure successful experimental results, the procedures are presented as either general methods or as specific applications to substance classes and special compounds, with emphasis on high performance liquid chromatography and capillary electrophoresis techniques, but also including thin layer chromotographic, gas chromatographic, supercritical fluid chromatographic as well as recent electrochromotographic techniques.
Categories: Science

Chiral Separations By Liquid Chromatography And Related Technologies

Chiral Separations By Liquid Chromatography And Related Technologies

Unique in its systematic and detailed description of the various types, structures, and properties of chiral stationary phases (CSPs) and their preparation, application, and future scope, this volume highlights an assortment of liquid ...

Author: Hassan Y. Aboul-Enein

Publisher: CRC Press

ISBN: 0203911113

Category: Science

Page: 400

View: 945

Unique in its systematic and detailed description of the various types, structures, and properties of chiral stationary phases (CSPs) and their preparation, application, and future scope, this volume highlights an assortment of liquid chromatographic approaches, including sub- and super-critical fluid chromatography, capillary electrochromatography
Categories: Science

Chiral Separation Techniques

Chiral Separation Techniques

This is a completely revised and updated sequel to 'A Practical Approach to Chiral Separations by Liquid Chromatography' by the same editor.

Author: G. Subramanian

Publisher: Wiley-VCH

ISBN: UOM:39015053518059

Category: Science

Page: 350

View: 882

This is a completely revised and updated sequel to 'A Practical Approach to Chiral Separations by Liquid Chromatography' by the same editor. The scope has been extended to further chiral separation techniques like electrophoresis, membrane separations, or biological assays. More emphasis is put on preparative separation techniques. From reviews of the previous edition: 'A team of experts from academic and industrial laboratories throughout the world have compiled their findings and experience to make this book an exceptionally timely and unique contribution to the field' European Journal of Drug Metabolism 'The dense mass of information contained in this book will make it a valuable resource ...' Chemical Engineering Research '... this is a worthwhile addition to the expanding chiral literature and the book should be of value to those working in this field' The Analyst
Categories: Science

Chiral Separation

Chiral Separation

This book focuses on the chiral separation of some important pharmaceuticals using two major approaches; one is pre-column derivatization with a chiral reagent followed by separation of resulting diastereomers known as 'indirect approach'.

Author: Shivani Tanwar

Publisher: LAP Lambert Academic Publishing

ISBN: 3659102938

Category:

Page: 196

View: 191

Biological in vivo processes are stereochemically controlled and rate limited by proper selection of enantiomers. Wrong selection can have deleterious effects, therefore, more than 40% of drugs (over the retail counters and prescribed) are indeed chiral, and of these 25% are supplied as pure enantiomers. So chiral separation has remained interesting and still challenging task for oneself to develop the new, simple, reproducible and sensitive methods. This book focuses on the chiral separation of some important pharmaceuticals using two major approaches; one is pre-column derivatization with a chiral reagent followed by separation of resulting diastereomers known as 'indirect approach'. The other one is 'direct approach' which may use a chiral mobile phase additive (CMPA) or a chiral stationary phase (CSP) or the chiral selector is immobilized/ impregnated with the stationary phase.
Categories:

Thin Layer Chromatography in Chiral Separations and Analysis

Thin Layer Chromatography in Chiral Separations and Analysis

A fast, inexpensive, and versatile separation technique, there are many practical considerations that contribute to its effectiveness. Thin Layer Chromatography in Chiral Separations and Analysis is the first bo

Author: Teresa Kowalska

Publisher: CRC Press

ISBN: 9780849343964

Category: Medical

Page: 436

View: 671

Thin layer chromatography (TLC) is well suited for performing enantioseparations for research as well as larger-scale applications. A fast, inexpensive, and versatile separation technique, there are many practical considerations that contribute to its effectiveness. Thin Layer Chromatography in Chiral Separations and Analysis is the first bo
Categories: Medical

Chiral Separations

Chiral Separations

This collection of papers has been published to widen the dissemination of the Special Issue of Journal of Chromatography: A Vol. 906, Nos. 1-2 published in January 2001.

Author: Bezhan Chankvetadze

Publisher: Elsevier Science Limited

ISBN: 0444506985

Category: Science

Page: 489

View: 283

From the contents: Chiral chromatographic separations based on ligand exchange (A. Kurganov). - Chiral separations using the macrocyclic antibiotics: a review (T.J. Ward, A.B. Farris III). - High-performace liquid chromatographic and capillary electrophoretic enantioseparation of plant growth regulators and related indole conpounds using macrocyclic antibiotics as chiral selectors (Review) (F. Hui et al.). -Polysaccaride-based chiral stationary phases for high-performance liquid chromtaographic enantioseparation (Review) (E. Yashima).
Categories: Science

Design of Chiral Separations by Liquid Chromatography and Capillary Electrophoresis for Amlodipine and Derivatives

Design of Chiral Separations by Liquid Chromatography and Capillary Electrophoresis for Amlodipine and Derivatives

The design of chiral separations in liquid chromatography (LC) and capillary electrophoresis (CE) involves the selection of chiral selectors and eluent parameters, often on a purely empirical basis.

Author: Tracy Sharon Small

Publisher:

ISBN: OCLC:1179621948

Category:

Page: 224

View: 984

The design of chiral separations in liquid chromatography (LC) and capillary electrophoresis (CE) involves the selection of chiral selectors and eluent parameters, often on a purely empirical basis. It would be desirable if rapid screening methods could be designed to rationalise the choice of these chiral selectors. With reference to the use of cyclodextrin (CD) derivatives as chiral selectors, nuclear magnetic resonance spectroscopy (NMR) can play an important role in screening the extent of interactions with chiral solutes, and in probing the nature of the stereoselective interactions involved. Data from high-field NMR on drugs and their derivatives have been explored for screening a number of potential chiral recognition agents, as an aid to the rational design of chiral separations by LC and CE, based on cyclodextrins (alpha, beta, gamma, hydroxypropyl-beta and hydroxyethyl-beta) bonded to silica (LC) and in free solution (CE). In this investigation high-field FT-NMR is used to examine the interaction mechanism between these cyclodextrins and the calcium channel blocker Amlodipine together with a series of its structural analogues. Enantiomeric interactions between the cyclodextrins and Amlodipine are explored using ROESY (rotating frame nuclear Overhauser effect spectroscopy) in order to determine the inclusion mechanism involved......
Categories:

Chiral Recognition in Separation Methods

Chiral Recognition in Separation Methods

The coverage in this book includes a range of separation methods, such as gas, liquid, or countercurrent chromatography, and capillary electrophoresis. The special case of chiral ionic liquids is examined in detail.

Author: Alain Berthod

Publisher: Springer Science & Business Media

ISBN: 3642124453

Category: Science

Page: 337

View: 404

What drives a scientist to edit a book on a speci c scienti c subject such as chiral mechanisms in separation methods? Until December 2005, the journal Analytical Chemistry of the American Chemical Society (Washington, DC) had an A-page section that was dedicated to simple and clear presentations of the most recent te- niques or the state of the art in a particular eld or topic. The “A-page” section was prepared for a broad audience of chemists including industrial professionals, s- dents as well as academics looking for information outside their eld of expertise. 1 Daniel W. Armstrong, one of the editors of this journal and a twenty-year+ long friend, invited me to present my view on chiral recognition mechanisms in a simple and clear way in an “A-page” article. In 2006, the “A-page” section was maintained as the rst articles at the beginning of each rst bi-monthly issue but the pagination was no longer page distinguished from the regular research articles published by the journal. During the time between the invitation and the submission, the A-page section was integrated into the rest of the journal and the article appeared as (2006) Anal Chem (78):2093–2099.
Categories: Science

Chiral Separations

Chiral Separations

This detailed book focuses on analytical separations by chromatographic and electrophoretic techniques, providing some overview along with numerous practically-oriented applications of the most important analytical techniques in chiral ...

Author: Gerhard K.E. Scriba

Publisher: Humana

ISBN: 1493994379

Category: Medical

Page: 487

View: 173

This detailed book focuses on analytical separations by chromatographic and electrophoretic techniques, providing some overview along with numerous practically-oriented applications of the most important analytical techniques in chiral separation sciences. While some compounds may only be enantioseparated with one technique based on the physico-chemical properties, often the analyst can choose between two or more analytical techniques for a given analyte, which requires knowledge of the strengths and weaknesses of each technique in order to select the most appropriate method for the given problem. This collection binds that knowledge in one volume. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Chiral Separations: Methods and Protocols, Third Edition serves as a helpful guide for analytical chemists working on stereochemical problems in the fields of pharmacy, chemistry, biochemistry, food chemistry, molecular biology, forensics, environmental sciences, or cosmetics in academia, government, or industry.
Categories: Medical

Enantiomer Separation

Enantiomer Separation

Accordingly, “Enantiomer Separation” is used in the title of this book. The editor and all chapter contributors hope that this book is helpful for scientists and engineers working in this field.

Author: Fumio Toda

Publisher: Springer Science & Business Media

ISBN: 9781402023378

Category: Science

Page: 333

View: 112

In spite of important advances in asymmetric synthesis, chiral compounds cannot all be obtained in a pure state by asymmetric synthesis. As a result, enantiomer separation remains an important technique for obtaining optically active materials. Although asymmetric synthesis is a once-only procedure, an enantiomer separation process can be repeated until the optically pure sample is obtained. This book discusses several new enantiomer separation methods using modern techniques developed by experts in the field. These methods consist mainly of the following three types: 1) Enantiomer separation by inclusion complexation with a chiral host compound 2) Enantiomer separation using biological methods 3) Enantiomer separation by HPLC chromatography using a column containing a chiral stationary phase. Separation of a racemic compound has been called “optical resolution” or simply “resolution”. Nowadays, the descriptions “enantiomer resolution” or “enantiomer separation” are also commonly used. Accordingly, “Enantiomer Separation” is used in the title of this book. The editor and all chapter contributors hope that this book is helpful for scientists and engineers working in this field.
Categories: Science

Chiral Separations

Chiral Separations

The second edition of Chiral Separations: Methods and Protocols, expands upon the previous edition with current methodology, providing an overview and especially practically oriented applications of the most important analytical techniques ...

Author: Gerhard K.E. Scriba

Publisher: Humana Press

ISBN: 1627032622

Category: Science

Page: 531

View: 920

There is a demand for analytical methods that are able to discriminate between enantiomers in order to analyze the enantiomeric purity of compounds from natural or chemical sources not only in pharmaceutical sciences but in any field on bioactive compounds including chemistry, biology, biochemistry, forensic, and environmental sciences and many others. The second edition of Chiral Separations: Methods and Protocols, expands upon the previous edition with current methodology, providing an overview and especially practically oriented applications of the most important analytical techniques in chiral separation sciences. New chapters on analytical separation sciences by chromatographic and electrophoretic techniques have been added as has simulated moving bed chromatography as a preparative method. Written in the highly successful Methods in Molecular BiologyTM series format, the chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Chiral Separations: Methods and Protocols, Second Edition is helpful for analytical chemists working on stereochemical problems in fields or pharmacy, chemistry, biochemistry, food chemistry, molecular biology, forensics, environmental sciences or cosmetics in academia, government or industry.
Categories: Science

Chiral Separation Techniques

Chiral Separation Techniques

4. Chiral. Separations. Using. Supercritical. Fluid. Chromatography. Karen W.
Phinney and Rodger W. Stringham 4.1 ... The importance of chirality in biological
activity is now well established and, as a result, chromatographic separations of ...

Author: Ganapathy Subramanian

Publisher: John Wiley & Sons

ISBN: 9783527611720

Category: Science

Page: 641

View: 996

Thoroughly revised, with either entirely new or completely updated contents, this is a practical manual for the small and large-scale preparation of enantiomerically pure products. The result is a vital resource for meeting the highest purity standards in the manufacture of chiral pharmaceuticals, food additives and related compounds. All the approaches covered here are highly relevant to modern manufacturing and quality control schemes in the pharmaceutical and biotech industries, addressing the increasingly important issue of drug safety in view of tougher regulatory standards worldwide.
Categories: Science

Chiral Separations by Liquid Chromatography

Chiral Separations by Liquid Chromatography

Chiral selectivity of cyclodextrins , cyclodextrin - bonded stationary phases in
HPLC , 74 – 82 Chiral selectors examples , 155 , 1560 , 157 types , 164 Chiral
separation chromatographic methods , 4 , 51 , 6 criteria , 127 growth of
methodology ...

Author: Satinder Ahuja

Publisher: Amer Chemical Society

ISBN: UOM:39015024892864

Category: Science

Page: 239

View: 181

A definitive reference for researchers working on problems involving chirality. Presenting state-of-the-art information, this volume covers all the major modes of separation and offers contributions from the leading researchers who developed these techniques. Four chapters provide a detailed review of the commonly used columns: brush type, cyclodextrin, polysaccaride carbonate, and protein. Many of the papers focus on HPLC, a technique which is also ideally suited for large scale preparation of optical isomers. In addition, the volume provides significant discussion on the use of chiral discriminators or selectors.
Categories: Science

Modified Cyclodextrins for Chiral Separation

Modified Cyclodextrins for Chiral Separation

2.14 Gas chromatographic enantiomeric separation of different classes of
compounds on CSP2.28. 20 mX0.25 mm fused-silica ... In addition, the most
important element in the GC enantioseparation process is the chiral selector.
Cyclodextrin ...

Author: Weihua Tang

Publisher: Springer Science & Business Media

ISBN: 9783642376481

Category: Science

Page: 258

View: 922

Modified Cyclodextrins for Chiral Separation offers a review of the latest advances in developing modified cyclodextrins as chiral selectors for various chromatographic and electromigration techniques. Over the years, many descriptions of chiral separation have appeared in academic journals and books, but most of them have been devoted to either the development of analytical methods and protocols or the summary of different chiral selectors, including cyclodextrins for chiral separation applications. This is in marked contrast to this volume which focuses on the research endeavors concerning the development of cyclodextrin derivatives specifically as either chiral mobile phases for capillary electrophoresis, or chiral stationary phases for various chromatographic techniques including gas chromatography, or high-performance liquid chromatography and supercritical fluid chromatography. The ongoing thread in this book is the synthesis of structurally-defined cyclodextrin derivatives and their applications in enantiomer separation by means of different analytical techniques. Modified Cyclodextrins for Chiral Separation is intended for those who are interested in expanding their knowledge of cyclodextrin chemistry and chiral separation, and in what cyclodextrin modification can be made to suit the needs of chiral selectors for different analytical techniques. It primarily focuses on the state-of-the-art cyclodextrin chemistry which is the basis for all chiral selectors used in these chiral separation techniques. Weihua Tang, PhD, is a professor at the Key Laboratory of Soft Chemistry and Functional Materials, Ministry of Education, Nanjing University of Science and Technology, China. Siu-Choon Ng, PhD, is a professor at the Division of Chemical and Biomedical Engineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore. Dongping Sun, PhD, is a professor at the Key Laboratory of Soft Chemistry and Functional Materials, Ministry of Education, Nanjing University of Science and Technology, China.
Categories: Science

Chromatography and Separation Science

Chromatography and Separation Science

The basic objectives of this book are to: provide basic information on chromatography and separation science; show how simple extraction and partition processes provide the basis for development of chromatography and separation science; ...

Author: Satinder Ahuja

Publisher: Academic Press

ISBN: 0120449811

Category: Science

Page: 250

View: 579

The basic objectives of this book are to: provide basic information on chromatography and separation science; show how simple extraction and partition processes provide the basis for development of chromatography and separation science; describe the role of chromatography and separation science in various fields; discuss the role of chromatography and separation science in development of new methodology; and present new evolving methods and how to select an optimum method. · The book covers the fundamental physical and chemical phenomena involved in separations · Provides a concise overview of the basics of transport phenomena and thermodynamics · Shows the importance of chromatography within separation science
Categories: Science

Recent Advances in Chiral Separations

Recent Advances in Chiral Separations

The difference in 95% confidence limits correlates with sample loading, 50 pig for
ephedrine hydrochloride and 20 pig for fluazifop-P-butyl. The achiral method
carries a little more uncertainty than does chiral chromatography, in part because
it ...

Author: D. Stevenson

Publisher: Springer Science & Business Media

ISBN: 9781468482829

Category: Medical

Page: 230

View: 657

This volume represents the proceedings of the second international meeting on chiral separations held at the University of Surrey between the 12th and 15th of September 1989. Like the preceding meeting, it was jointly organised by the Chromatographic Society and the Robens Institute of the University of Surrey in response to the continued interest in this area of separation science. Of particular interest to the organisers was the very clear change in the nature of the delegates attending this second symposium as compared with the first. At the previous meeting the majority of the delegates were composed of chromatographers with problems in the area of chiral separations who were keen to learn as much as possible about these techniques from the handful of recognised experts in this area. In this second symposium the divide between expert and novice was much less apparent, with the latter providing many interesting and useful contributions to the scientific programme in termt; of both oral and poster presentations.
Categories: Medical

Chiral Environmental Pollutants

Chiral Environmental Pollutants

Investigations with unmodified cyclodextrins showed that they may function as
chiral shift reagents in solution together with a racemic substrate ... König WA (
1987 ) The practice of enantiomer separation by capillary gas chromatography .

Author: R. Kallenborn

Publisher: Springer Science & Business Media

ISBN: 3540664238

Category: Science

Page: 210

View: 914

This monograph contains a survey on the role of chirality in ecotoxicological processes. The focus is on environmental trace analysis. Areas such as toxicology, ecotoxicology, synthetic chemistry, biology, and physics are also covered in detail in order to explain the different properties of enantiomers in environmental samples. This monograph delivers a comprehensive survey for environmental trace analysts, analytical chemists, ecotoxicologists, food scientists and experienced lab workers.
Categories: Science