A Handbook of Mouse Models of Cardiovascular Disease

A Handbook of Mouse Models of Cardiovascular Disease

A Handbook of Mouse Models of Cardiovascular Disease: Describes mouse models of all important cardiovascular diseases, including atherosclerosis, atrial fibrillation and thrombosis Features videos of key experimental procedures on the ...

Author: Qingbo Xu

Publisher: John Wiley & Sons

ISBN: 9780470028780

Category: Science

Page: 402

View: 624

The availability of well-defined genetic strains and the ability to create transgenic and knockout mice makes mouse models extremely valuable biomedical tools. Their suitability as an experimental system for cardiovascular research depends on the individual investigator’s ability to manipulate the mice surgically. Many mouse models require microsurgical techniques, which hitherto could not be performed without practical training. This comprehensive handbook enables scientists to develop these models in their own laboratories. A Handbook of Mouse Models of Cardiovascular Disease is the first book to address pathology in mouse models of heart disease, providing the reader with essential information on technical assays in artificially created models. It includes background information on individual cardiovascular diseases, describes detailed methods and materials used for establishing each mouse model, discusses the problems that may appear in the experiments, and provides examples of applications of the model. A Handbook of Mouse Models of Cardiovascular Disease: Describes mouse models of all important cardiovascular diseases, including atherosclerosis, atrial fibrillation and thrombosis Features videos of key experimental procedures on the accompanying CD, allowing researchers to learn the techniques by directly watching the whole operational procedure Describes how to establish each experimental model with detailed protocols and tips on dealing with common operational problems Highlights potential applications of each model in areas such as pathogenesis, gene transfer, therapy and pathophysiology This handbook is an invaluable resource for researchers in cardiovascular disease, pathology, physiology, interested in the mechanism of vascular disorders and therapeutic approaches. It is also relevant to clinicians seeking to understand the pathology of cardiovascular disease and the rationale for interventions, and of interest to the pharmaceutical industry and all those involved in drug discovery/development for cardiovascular disease.
Categories: Science

Heart Research on Animals

Heart Research on Animals

Author: Brandon Kuker-Reines

Publisher:

ISBN: UOM:39015009579007

Category: Animal experimentation

Page: 82

View: 775

Categories: Animal experimentation

Animal models in cardiovascular research

Animal models in cardiovascular research

Concepts derived from cell biology and animal model studies, Arch Pathol Lab
Med, 107:393-399, 1983 3. Roach, M.R., Smith N.B.; Does high shear stress
induced by blood flow lead to atherosclerosis?, Perspect Biol Med, 26:287-303,
1983 ...

Author: D.R. Gross

Publisher: Springer Science & Business Media

ISBN: 9789401707305

Category: Medical

Page: 501

View: 709

Interest in the humane and scientifically justifiable use of research animals has intensified since the publication of the first edition of this textbook. This completely revised and updated text provides information essential to any researcher interested in using animal models for cardiovascular research, or any research which requires normal cardiovascular function. The format and presentation have been changed to make the text more easy to read and use. An introductory chapter offers general principles of animal selection, pre and post-operative care, preanesthesia, chemical restraint, analgesia, and the recognition of pain. The number of references cited has been almost doubled over the previous text and the chapter tabulating normal cardiovascular parameters from intact, awake animals, of those species commonly used in research, has been greatly expanded. Other chapters providing comprehensive data on the cardiovascular effects of opioids, tranquilizers, anesthetic agents and other drugs commonly used in cardiovascular research have been expanded with special emphasis on species variability to drug effects. The chapters on both naturally occurring and iatrogenic models of cardiovascular disease have also been expanded and updated.
Categories: Medical

Animal Models in Cardiovascular Research

Animal Models in Cardiovascular Research

The cardiac ryanodine receptor (RyR2) regulates calcium release from the
sarcoplasmic reticulum (SR). Mutations in this receptor result in ... Animal Models
in Cardiovascular Research, 2nd Revised Edition. Boston, MA: Kluwer Academic;
 ...

Author: David Gross

Publisher: Springer Science & Business Media

ISBN: 0387959629

Category: Science

Page: 431

View: 864

Interest in the humane and scientifically justifiable use of research animals has intensified since the publication of the 2nd edition of Animal Models in Cardiovascular Research. This completely revised and updated edition will provide information essential to any researcher interested in using animal models for cardiovascular research, or any research which requires normal cardiovascular function. The format and presentation will be changed to make the text more easy to read and use: (1) This edition is in outline format, for ease and utility. (2) The opening chapter includes more information on the cardiovascular effects of post-operative analgesia and will address the recognition of pain behavior in species commonly used in research settings, particularly rats and mice. (3) New edition includes reference material more useful to researchers using transgenic and naturally occurring animal models to dissect these mechanisms.
Categories: Science

Handbook of Laboratory Animal Science

Handbook of Laboratory Animal Science

Chapter 5 Animal Models for Cardiovascular Research Timo Nevalainen . ... As a
consequence , much non - clinical cardiovascular research focuses on modeling
human circulatory diseases in experimental animals . Human hearts are similar ...

Author: Jann Hau

Publisher: CRC Press

ISBN: 0849343909

Category: Medical

Page: 224

View: 947

This two-volume set presents a comprehensive description of laboratory animal genetics, diseases, health monitoring, nutrition, and the environmental impact on animal testing. It considers the ethics of animal experimentation through a complete review of European and North American legislation on the topic. It discusses alternatives to animal experiments, including the use of isolated organs, cell cultures, and computer simulations. The book also examines general methods, including experimental design and statistical evaluation, non-surgical and surgical techniques, anesthesia, and post-mortem examinations. Reviews of animal models for studying diseases of different organ systems, infectious diseases, cancer, and toxicology are featured as well.
Categories: Medical

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease

The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models ...

Author: P. Michael Conn

Publisher: Academic Press

ISBN: 9780124159129

Category: Science

Page: 1108

View: 292

Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders, cancer, hypertension, genetic diseases, and diseases of abuse. Organized by disease orientation for ease of searchability Provides information on locating resources, animal alternatives and animal ethics Covers a broad range of animal models used in research for human disease
Categories: Science

Animal models in cardiovascular research

Animal models in cardiovascular research

The text provides an extensive tabulation of normal cardiovascular parameters
from intact, awake animals of most species commonly used in research. There
are chapters on both naturally occurring and iatrogenic models of cardiovascular
 ...

Author:

Publisher:

ISBN: UCAL:B4979672

Category:

Page:

View: 394

Categories:

Cardiovascular Disease

Cardiovascular Disease

9 Animal Models for Cardiac Arrhythmias Sandro L. Yong and Qing K. Wang
Summary Transgenic and gene-targeted ... used to expand the study of cardiac
physiology and pathophysiology owing to the ease with which the mouse
genome ...

Author: Qing Wang

Publisher: Springer Science & Business Media

ISBN: 9781597452137

Category: Medical

Page: 400

View: 976

The two volumes of Cardiovascular Disease: Methods and Protocols provide comprehensive coverage of both basic and advanced approaches to the study and characterization of cardiovascular disease. In Volume 1: Genetics and Volume 2: Molecular Medicine, highly experienced cardiovascular researchers describe in detail the most important techniques in molecular medicine that are employed in genetic, molecular, cellular, structural, and physiological studies of cardiovascular disease.
Categories: Medical

Animal Models of Human Disease

Animal Models of Human Disease

Dissection of Cardiovascular Development and Disease Pathways in Zebrafish
Joanne Chan*,{ and John D. Mablyz,} *Vascular Biology Program, Children's
Hospital Boston, Harvard ... Current Animal Models of Cardiovascular Disease .

Author:

Publisher: Academic Press

ISBN: 9780123848796

Category: Science

Page: 550

View: 248

Animal experiments have contributed much to our understanding of mechanisms of disease and are important for determining new therapies. This volume reviews the latest research and developments in this field. * Discusses new discoveries, approaches, and ideas * Contributions from leading scholars and industry experts * Reference guide for researchers involved in molecular biology and related fields
Categories: Science

Handbook of Laboratory Animal Science Volume III

Handbook of Laboratory Animal Science  Volume III

Animal. Models. of. Cardiovascular. Disease. Meg Sleeper CONtENtS Naturally
Occurring Large Animal Models of Inherited Diseases Affecting the Heart..............
108 Naturally Occurring Models of Cardiomyopathy.

Author: Jann Hau

Publisher: CRC Press

ISBN: 9781466555136

Category: Medical

Page: 334

View: 779

While replacing and reducing the use of laboratory animals are integral parts of the 3Rs-replace, reduce, refine-which form the cornerstones of laboratory animal science, biomedical research involving animals remains absolutely essential for the advancement of the medical, veterinary, agricultural, and biological sciences. Building upon the bestsel
Categories: Medical

Molecular Genetics of Cardiac Electrophysiology

Molecular Genetics of Cardiac Electrophysiology

Animal models ofcardiac arrhythmias are an increasingly important source
ofunderstanding for the mechanisms associatedwith human disease. In thestudy
of future potential therapiesfor cardiac arrhythmias, themost appropriate animal ...

Author: C. Berul

Publisher: Springer Science & Business Media

ISBN: 9781461545170

Category: Medical

Page: 378

View: 744

The molecular basis for atrial fibrillation continues to be largely unknown, and therapy remains unchanged, aimed at controlling the heart rate and preventing systemic emboli with anticoagulation. Familial atrial fibrillation is more common than previously suspected. While atrial fibrillation is commonly associated with acquired heart disease, a significant proportion of individuals have early onset without other forms of heart disease, referred to as "lone" atrial fibrillators. It is also well recognized that atrial fibrillation occurs on a reversible or functional basis, without associated structural heart disease, such as with hyperthyroidism or of atrial fibrillation following surgery. It remains to be determined what percentage in these individuals is familial or due to a genetic predisposition. Mapping the locus for familial atrial fibrillation is the first step towards the identification of the gene. Isolation of the gene and subsequent identification of the responsible molecular genetic defect should provide a point of entry into the mechanism responsible for the familial form and the common acquired forms of the disease and eventually provide more effective therapy. We know that the ionic currents responsible for the action potential of the atrium is due to multiple channel proteins as is electrical conduction throughout the atria. Analogous to the ongoing genetic studies in patients with familial long QT syndrome, it is highly likely that defects in each of these channel proteins will be manifested in familial atrial fibrillation.
Categories: Medical

Introduction to Translational Cardiovascular Research

Introduction to Translational Cardiovascular Research

Dennis V. Cokkinos. Part IV Man and Animals 19 Animal Models of
Cardiovascular Disease Inês Falcão-Pires and Adelino Part IV: Man and Animals
.

Author: Dennis V. Cokkinos

Publisher: Springer

ISBN: 9783319087986

Category: Medical

Page: 610

View: 945

The term “Translational Research” reflects today’s integration of basic research (“bench”) findings with the clinical practice of medicine, and in a wider scope the application of results from the individual patient (“bedside”) to entire populations for the improvement of public health. This book offers future researchers a stimulus in many aspects of cardiovascular research, so as to promote their interest in future fields of cardiovascular disease, diagnosis and treatment. Introduction to Translational Cardiovascular Research discusses the fundamental and important aspects of the topic. It describes the renin-angiotensin-aldosterone system, the beta adrenergic receptors and the hypothalamic-pituitary-adrenal axis, while covering genetic polymorphisms both generally and specifically as regards the vascular endothelium and the use of microRNAs. As such, this book will be relevant to young physicians, nurses and other scientists engaged in the clinical cardiovascular field who want to added research-oriented dimension to their efforts towards better understanding and practicing of medicine. It also aims to attract young basic researchers who want to develop a better comprehension of the organism as a whole, man or animal, that they are investigating.
Categories: Medical

Clinical Nuclear Cardiology State of the Art and Future Directions E Book

Clinical Nuclear Cardiology  State of the Art and Future Directions E Book

Bader M, Bohnemeier H, Zollmann F, Lockley-Jones O, Ganten D: Transgenic
animals in cardiovascular disease research, Exp Physiol 85:713–731, 2000.
Carmeliet P, Collen D: Transgenic mouse models in angiogenesis and
cardiovascular ...

Author: Barry L. Zaret

Publisher: Elsevier Health Sciences

ISBN: 9780323085724

Category: Medical

Page: 896

View: 634

Clinical Nuclear Cardiology—now in its fourth edition—covers the tremendous clinical growth in this field, focusing on new instrumentation and techniques. Drs. Barry L. Zaret and George A Beller address the latest developments in technology, radiopharmaceuticals, molecular imaging, and perfusion imaging. Thoroughly revised to include 20 new chapters—Digital/Fast SPECT, Imaging in Revascularized Patients, and more—this new edition provides state-of-the-art guidance on key areas and hot topics with stunning visuals. Online access to the fully searchable text at expertconsult.com includes highly illustrated case studies that let you see the problem using a variety of imaging modalities. In other words, this is an invaluable resource no clinician or researcher in nuclear cardiology should be without. Features an editorial and contributing team of worldwide leaders in nuclear cardiology to provide you with current and authoritative guidance. Includes a section focusing on acute coronary syndromes to provide you with practical management tools for these conditions. Presents a full-color design that allows color images to be integrated throughout the text. Includes access to the fully searchable contents of the book online at expertconsult.com, along with highly illustrated case studies that let you see the problem using a variety of imaging modalities. Features 20 new chapters including Cellular Mechanisms of Tracer Uptake and Clearance; Attenuation/Scatter Corrections: Clinical Aspects; Hybrid Imaging; Digital/Fast SPECT; Imaging in Revascularized Patients; and more. Focuses on perfusion imaging in a section dedicated to this hot topic so you get all the information you need to stay current.
Categories: Medical

Animal Models in Biomedical Research

Animal Models in Biomedical Research

062 " Alcohol - induced congestive cardiomyopathy : An animal model . " G.R.
Noren , N.A. Staley , S. Einzig , F.L. Mikell , and R.W. Asinger , Cardiovascular
Research 17 ( 2 ) : 81-87 ( February 1983 ) . NAL call number : QM178 A1C38 ...

Author:

Publisher: DIANE Publishing

ISBN: 1568069243

Category:

Page: 80

View: 406

Categories:

Practical Methods in Cardiovascular Research

Practical Methods in Cardiovascular Research

Sufficient anaesthesia is a prerequisite for any intervention using laboratory
animals for scientific purposes. ... In the following chapters, protocols for general
anaesthesia will be described for those animals which are most often used for
scientific purposes in cardiovascular research. ... 5 Models of Cardiovascular
Diseases Anaesthesia (Inhalative or i v Narcosis) of Laboratory Animals Katja
Schneider.

Author: Stefan Dhein

Publisher: Springer

ISBN: 3540265740

Category: Medical

Page: 1010

View: 524

Scientists working or planning to work in the field of cardiovascular research will welcome Methods in Cardiovascular Research as the reference book they have been waiting for. Not only general aspects of cardiovascular research are well presented but also detailed descriptions of methods, protocols and practical examples. Written by leading scientists in their field, chapters cover classical methods such as the Langendorff heart or working heart models as well as numerous new techniques and methods. Newcomers and experienced researchers alike will benefit from the troubleshooting guide in each chapter, the extensive reference lists for advanced reading and the great practical experience of the authors. Methods in Cardiovascular Research is a "must have" for anybody with an interest in cardiovascular research.
Categories: Medical

Developmental Programming of Cardiovascular Disease

Developmental Programming of Cardiovascular Disease

Low birth weight, a surrogate marker of poor fetal growth, is linked to increased
risk for heart disease, hypertension, and stroke. Numerous animal models
support this association and provide insight into the mechanisms by which
adverse ...

Author: Barbara T. Alexander

Publisher: Biota Publishing

ISBN: 9781615046034

Category: Science

Page: 77

View: 976

Numerous epidemiological studies report that birth weight is inversely associated with blood pressure, suggesting that slow growth during fetal life programs hypertension and increased risk for cardiovascular disease in later life. Different experimental models are used to provide proof of concept for the theory of developmental programming of cardiovascular disease, and studies in these different animal models are providing insight into the etiology of chronic disease programmed by an imbalance in nutrition during early life or exposure to maternal complications during pregnancy. Alterations in the regulatory systems key to the long-term control of blood pressure are implicated in the etiology of hypertension that results from adverse exposures during early development. Epigenetic processes are also implicated in the increased risk for programmed cardiovascular disease and the passage of programmed cardiovascular risk to the next generation. Sex, age, and early postnatal growth impact later programmed risk; programmed risk is also amplified in response to a secondary challenge that includes normal physiological processes such as pregnancy. Thus, this book will highlight how events during early life impact later cardiovascular health in a manner that is sex- and age-dependent and can be transmitted to the next generation. Table of Contents: Introduction / Historical Perspective / Epidemiological Studies / Experimental Models of Developmental Programming / Mechanisms of Developmental Programming / Birth Weight and Clinical Considerations / Birth Weight and Cardiovascular Disease: Translational Considerations / Summary and Conclusions / References / Author Biography
Categories: Science

Advances in Swine in Biomedical Research

Advances in Swine in Biomedical Research

In 1995, over 10% of all NIH grants employing swine as a research animal model
were awarded in the area of ... in which pigs are utilized as animal models for
research on cardiovascular, renal, respiratory and gastroenterohepatic function.

Author: L.B. Schook

Publisher: Springer Science & Business Media

ISBN: 0306454955

Category: Medical

Page: 422

View: 116

Contains papers from the October 1995 symposium, in sections on general aspects, transgenics, and immunology and infectious diseases. Topics include ultrastructure of the liver in piglets fed dietary oils, artificial surfactant as a vehicle for endotracheal epinephrine in pediatric porcine cardiopul
Categories: Medical

Hormone Replacement Therapy and Cardiovascular Disease

Hormone Replacement Therapy and Cardiovascular Disease

The Current Status of Research and Practice A.R. Genazzani. 13 Sex steroids
and the cardiovascular system in vivo : actions in animal models J. K. Williams
BRIEF REVIEW OF ANIMAL STUDIES Studies on animal models , particularly
during ...

Author: A.R. Genazzani

Publisher: CRC Press

ISBN: 1842140388

Category: Medical

Page: 200

View: 581

This is a high-level, clinical reference by world-class specialists on the efficacy of hormone replacement therapy for the primary prevention of cardiovascular risk in postmenopausal women. Specific chapters cover pulsed estrogen therapy with Aerodiol and cardiovascular risk assessment in postmenopausal hormone replacement therapies such as Livial (tibolone). This volume is based on the formal presentations and subsequent discussions that took place at the International Menopause Society specially convened Expert Workshop on Hormone Replacement Therapy and Cardiovascular Disease, London, UK, October 13-16, 2000.
Categories: Medical

Diabetes and Cardiovascular Disease

Diabetes and Cardiovascular Disease

TYPE 2 DIABETES : PHARMACOLOGICAL INTERVENTION IN AN ANIMAL
MODEL James C. Russell Department of Surgery 275 Heritage Medical
Research Centre University of Alberta Edmonton , Alberta INTRODUCTION The
state of ...

Author: Aubie Angel

Publisher: Springer Science & Business Media

ISBN: 0306466376

Category: Medical

Page: 415

View: 781

Diabetes and cardiovascular disease together account for the largest portion of health care spending compared to all other diseases in Western society. This work seeks to provide an understanding of the causes of diabetes and its cardiovascular complications. As this understanding becomes more widely appreciated, it will serve as a foundation for evidence-based care and wider acceptance of sound science. The International Conference on Diabetes and Cardiovascular Disease, held in Winnipeg, in June 1999, was organized to bring together a multi-disciplinary group of researchers dedicated to further knowledge amongst researchers, care givers, and the managers of the health system. The invited speakers submitted their works for publication, which serves as the basis for this book. Major themes include: epidemiology of diabetes mellitus, metabolic risk factors in diabetes and cardiovascular disease, hypertension in diabetes mellitus, cardiac function in diabetes, glycemic control and improved cardiovascular function, diabetes management, and endothelial function in diabetes.
Categories: Medical

Animal Models in Diabetes

Animal Models in Diabetes

12 THE JCR: LA-cp RAT: AN ANIMAL MODEL OF OBESITY AND INSULIN
RESISTANCE WITH SPONTANEOUS CARDIOVASCULAR DISEASE J.C.
RUSSELL and S.E.GRAHAM Department of Surgery, University of Alberta,
Edmonton, ...

Author: Eleazar Shafrir

Publisher: CRC Press

ISBN: 9780203304730

Category: Medical

Page: 380

View: 729

Animal Models of Diabetes: A Primer introduces characteristics of the most commonly used animal species with various diabetic syndromes which have been developed and extensively investigated during the last few decades. It includes animal models that are readily available, well described and proven to be of value in the research of both types of diabetes. Extensively referenced, this book will be of value to new and established investigators, graduate students and pharmaceutical scientists working on the development of antidiabetic and preventative modalities in various areas of diabetes and its complications.
Categories: Medical